Molecular Basis of Inheritance

Which one of the following statements about histones is wrong?

1. Histones carry positive charge in the side chain
2. Histones are organized to form a unit of 8 molecules
3. The pH of histones is slightly acidic
4. Histones are rich in amino acids - Lysine and Arginine

In the light of the above statements, choose the correct answer from the options given below.

1. Statement I is incorrect but Statement II is true
2. Both Statement I and Statement II are true
3. Both Statement I and Statement II are false
4. Statement I is correct but Statement II is false

If the distance between two consecutive base pairs is 0.34 nm and the total number of base pairs of a DNA double helix in a typical mammalian cell is 6.6 109 bp, then the length of the DNA is approximately

1. 2.7 meters
2. 2.0 meters
3. 2.5 meters
4. 2.2 meters

Which of the following statements is correct?

1. Adenine does not pair with thymine
2. Adenine pairs with thymine through one H-bond
3. Adenine pairs with thymine through two H-bonds
4. Adenine pairs with thymine through three H-bonds

The first phase of translation is

1. Recognition of an anti-codon
2. Recognition of DNA molecule
3. Binding of mRNA to ribosome
4. Aminoacylation of tRNA

Name the enzyme that facilitates opening of DNA helix during transcription.

1. DNA polymerase
2. RNA polymerase
3. DNA helicase
4. DNA ligase

Purines found both in DNA and RNA are:

1. Guanine and cytosine
2. Cytosine and thymine
3. Adenine and thymine
4. Adenine and guanine

Expressed Sequence Tags (ESTs) refers to :

1. DNA polymorphism
2. Novel DNA sequences
3. Genes expressed as RNA
4. Polypeptide expression

Under which of the following conditions will there be no change in the reading frame of following mRNA? 5' AACAGCGGUGCUAUU 3'

1. Insertion of A and G at 4th and 5th positions respectively
2. Deletion of GGU from 7th, 8th and 9th positions
3. Insertion of G at 5th position
4. Deletion of G from 5th position

Which of the following features of genetic code does allow bacteria to produce human insulin by recombinant DNA technology?

1. Genetic code is nearly universal
2. Genetic code is specific
3. Genetic code is not ambiguous
4. Genetic code is redundant