A male human is heterozygous for autosomal genes A and B and is also hemizygous for hemophilic gene h. What proportion of his sperms will be abh?
- 1/16
- 1/32
- 1/8
- 1/4
Answer
(3) 1/8
Solution
The male's genotype is AaBb XhY: the haemophilia gene h is on the X chromosome, and since the male has only one X, he is hemizygous.
A sperm carries a with probability 12, b with probability 12, and Xh (h) with probability 12 (the other half carry Y).
Because the genes segregate independently, the proportion of abh sperms = 12 12 12 = 18
Answer: (3)